Baugh Simon D P
Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, USA.
J Fungi (Basel). 2022 Oct 15;8(10):1085. doi: 10.3390/jof8101085.
The guanidine moiety is typically a highly basic group, and can be found in a wide variety of drugs, such as zanamivir (Relenza) and metformin (Fortamet), as well as in biologically active compounds for numerous disease areas, including central nervous system (CNS) diseases and chemotherapeutics. This review will focus on antifungal agents which contain at least one guanidine group, for the treatment of human-related fungal pathogens, described in the literature between 2004 and 2022. These compounds include small molecules, steroids, polymers, metal complexes, sesquiterpenes, natural products, and polypeptides. It shall be made clear that a diverse range of guanidine-containing derivatives have been published in the literature and have antifungal activity, including efficacy in experiments.
胍基通常是一个高度碱性的基团，存在于多种药物中，如扎那米韦（瑞乐沙）和二甲双胍（福美明），以及众多疾病领域的生物活性化合物中，包括中枢神经系统（CNS）疾病和化疗药物。本综述将聚焦于2004年至2022年间文献中描述的、含有至少一个胍基用于治疗人类相关真菌病原体的抗真菌剂。这些化合物包括小分子、类固醇、聚合物、金属配合物、倍半萜、天然产物和多肽。需要明确的是，文献中已发表了多种含胍基衍生物，它们具有抗真菌活性，包括在实验中的疗效。
