多环吲哚生物碱类化合物的 MCR 法合成。
Polycyclic indole alkaloid-type compounds by MCR.
机构信息
University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
出版信息
Chem Commun (Camb). 2010 Feb 7;46(5):770-2. doi: 10.1039/b917660h. Epub 2009 Dec 11.
DOI:10.1039/b917660h
PMID:20087515
Abstract
Polycyclic indole moieties are often part of bioactive natural or synthetic products, however traditionally have to be synthesized over several steps involving time consuming sequential multi-step syntheses. We herein communicate an efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction.
摘要
多环吲哚部分通常是生物活性天然或合成产物的一部分，然而传统上必须通过涉及耗时的顺序多步合成的几个步骤进行合成。在此，我们传达了一种有效的和灵活的两步法来合成复杂的多环吲哚生物碱型化合物，涉及 Ugi MCR 和 Pictet-Spengler 反应。
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