通过钛介导的分子内亲核酰取代策略的全合成（±）-subincanadine F 的 Aspidosperma 生物碱。
Total synthesis of the Aspidosperma alkaloid (±)-subincanadine F via a titanium-mediated intramolecular nucleophilic acyl substitution strategy.
机构信息
Department of Chemistry, The University of Vermont, 82 University Place, Burlington, Vermont 05405, USA.
出版信息
J Org Chem. 2010 Oct 15;75(20):7026-8. doi: 10.1021/jo1015823.
Abstract
The total synthesis of the bridge-fused Aspidosperma indole alkaloid (±)-subincanadine F has been accomplished in seven steps. The synthetic utility of a titanium-mediated intramolecular nucleophilic acyl substitution (INAS) reaction for the construction of the bridge-fused ring system was demonstrated.
摘要
桥环阿匹斯多精吲哚生物碱（±）-subincanadine F 的全合成已完成七步。钛介导的分子内亲核酰取代（INAS）反应在构建桥环系统中的合成应用得到了证明。
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