Tiesinga Paul, Sejnowski Terrence J
Donders Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands.
Neuron. 2009 Sep 24;63(6):727-32. doi: 10.1016/j.neuron.2009.09.009.
The response of a neuron to sensory stimuli can only give correlational support for functional hypotheses. To experimentally test causal function, the neural activity needs to be manipulated in a cell-type-specific as well as spatially and temporally precise way. We review recent optogenetic experiments on parvalbumin-positive cortical interneurons that link modeling studies of synchronization to experimental studies on attentional modulation of gamma oscillations in primates.
神经元对感觉刺激的反应只能为功能假说提供相关性支持。要通过实验测试因果功能,需要以细胞类型特异性以及空间和时间精确的方式来操纵神经活动。我们回顾了最近关于小白蛋白阳性皮质中间神经元的光遗传学实验,这些实验将同步的建模研究与灵长类动物中γ振荡的注意力调制的实验研究联系起来。