Division of Human Genetics, The Ohio State University, Columbus, OH, USA.
Cancer Causes Control. 2010 Jan;21(1):69-75. doi: 10.1007/s10552-009-9435-7. Epub 2009 Sep 25.
The Amish have not been previously studied for cancer incidence, yet they have the potential to help in the understanding of its environmental and genetic contributions. The purpose of this study was to estimate the incidence of cancer among the largest Amish population.
Adults from randomly selected households were interviewed and a detailed cancer family history was taken. Using both the household interview data and a search of the Ohio cancer registry data, a total of 191 cancer cases were identified between the years 1996 and 2003.
The age-adjusted cancer incidence rate for all cancers among the Amish adults was 60% of the age-adjusted adult rate in Ohio (389.5/10(5) vs. 646.9/10(5); p < 0.0001). The incidence rate for tobacco-related cancers in the Amish was 37% of the rate for Ohio adults (p < 0.0001). The incidence rate for non-tobacco-related cancers in the Amish was 72% of the age-adjusted adult rate in Ohio (p = 0.0001).
Cancer incidence is low in the Ohio Amish. These data strongly support reduction of cancer incidence by tobacco abstinence but cannot be explained solely on this basis. Understanding these contributions may help to identify additional important factors to target to reduce cancer among the non-Amish.
之前尚未对阿米什人的癌症发病率进行研究，但他们有可能帮助我们了解癌症的环境和遗传因素。本研究的目的是估算最大的阿米什人群中的癌症发病率。
从随机抽取的家庭中对成年人进行访谈，并详细记录癌症家族史。通过家庭访谈数据和俄亥俄癌症登记处数据的搜索，共确定了 1996 年至 2003 年间的 191 例癌症病例。
调整年龄后，阿米什成年人的所有癌症发病率为俄亥俄州成年人的 60%（389.5/10(5)与 646.9/10(5)；p < 0.0001）。阿米什人中与烟草相关的癌症发病率为俄亥俄州成年人的 37%（p < 0.0001）。阿米什人中与非烟草相关的癌症发病率为俄亥俄州成年人的 72%（p = 0.0001）。
俄亥俄州阿米什人的癌症发病率较低。这些数据强烈支持通过戒烟来降低癌症发病率，但不能仅以此为基础来解释。了解这些因素可能有助于确定针对非阿米什人群降低癌症发病率的其他重要因素。
