Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr-Universität Bochum, Germany.
Hum Brain Mapp. 2010 Apr;31(4):621-30. doi: 10.1002/hbm.20892.
Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects (N = 94) were genotyped for the functional 5-HT1A C(-1019)G polymorphism. The results show that the 5-HT1A C(-1019)G polymorphism specifically modulates error detection. Neurophysiological modulations on error detection were paralleled by a similar modulation of response slowing after an error, reflecting the behavioral adaptation. The 5-HT1A -1019 CC genotype group showed a larger Ne and stronger posterror slowing than the CG and GG genotype groups. More general processes of performance monitoring, as reflected in the Nc/CRN, were not affected. The finding that error-specific processes, but not general response monitoring processes, are modulated by the 5-HT1A C(-1019)G polymorphism is underlined by a wavelet analysis. In summary, the results suggest a specific effect of the 5-HT1A C(-1019)G polymorphism on error monitoring, as reflected in the Ne, and suggest a neurobiological dissociation between processes of error monitoring and general response monitoring at the level of the serotonin 1A receptor system.
我们的研究调查了对 5-羟色胺能系统具有调节作用的遗传因素对反应监控和错误检测的依赖性。这是通过错误（Ne/ERN）和正确（Nc/CRN）试验后的事件相关电位（ERP）来完成的。为了诱导足够数量的错误，使用了标准的侧抑制任务。对 94 名受试者进行了功能性 5-HT1A C(-1019)G 多态性的基因分型。结果表明，5-HT1A C(-1019)G 多态性特异性调节错误检测。错误检测的神经生理调节与错误后反应减速的类似调节相平行，反映了行为适应。5-HT1A-1019 CC 基因型组的 Ne 值较大，且错误后减速较强，而 CG 和 GG 基因型组则较小。更一般的反应监控过程，如 Nc/CRN 所反映的，不受影响。5-HT1A C(-1019)G 多态性对错误特异性过程而不是一般反应监控过程的调节，这一发现得到了小波分析的支持。总之，结果表明 5-HT1A C(-1019)G 多态性对 Ne 中的错误监控具有特定影响，并表明在 5-羟色胺 1A 受体系统水平上，错误监控和一般反应监控过程之间存在神经生物学分离。
