Department of Psychology, Centre for Innovation in Mental Health, University of Southampton, Southampton, UK.
Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, Center for Brain, Behaviour and Metabolism, University of Lübeck, Lübeck, Germany.
Sci Rep. 2017 Aug 10;7(1):7722. doi: 10.1038/s41598-017-08158-9.
Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.
证据表明，妥瑞氏症的特征是多巴胺传递增加，以及额纹体回路的结构和功能变化，这可能导致增强的多组件行为整合。使用停止-变化任务，从 15 名妥瑞氏症患者（平均年龄=30.40±11.10）和 15 名健康对照者（27.07±5.44）中收集了关于多组件行为的行为和神经生理学数据。在这个任务中，要求参与者有时对 Go 刺激（停止线索）不做出反应，并用另一只手对替代的 Go 刺激（改变线索）做出反应。为了改变任务难度，实施了不同的停止和改变线索之间的起始异步（0 和 300ms）。当停止和改变刺激之间没有延迟时，妥瑞氏症患者的反应比健康对照组更准确，而在 300ms 延迟条件下则没有差异。这种表现优势反映在较小的 P3 事件相关电位中。妥瑞氏症中的增强的多组件行为可能基于从多个来源整合信息并将其转化为适当的反应序列的能力增强。这可能是这些患者慢性抽搐控制的结果，或者是妥瑞氏症中已知的额纹体网络过度连通性的结果。
