State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P.R. China.
Small. 2009 Dec;5(23):2722-9. doi: 10.1002/smll.200900923.
This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.
本工作评价了球形介孔硅（MS）纳米和微颗粒的细胞毒性，并研究了颗粒尺寸、浓度、MS 的生物降解产物、残留表面活性剂以及通过提取和煅烧去除表面活性剂对细胞毒性的影响。不同尺寸的球形 MS 纳米和微颗粒的细胞内定位结果揭示了其细胞毒性的机制，即较小的纳米级颗粒更易被内吞，并因此位于溶酶体中。
