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本文引用的文献

1
Alpha-lactosylceramide as a novel "sugar-capped" CD1d ligand for natural killer T cells: biased cytokine profile and therapeutic activities.α-乳糖神经酰胺作为一种新型的天然杀伤性T细胞“糖封端”CD1d配体：偏向性细胞因子谱及治疗活性
Chembiochem. 2008 Jun 16;9(9):1423-30. doi: 10.1002/cbic.200700625.
2
A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.CD1d-糖脂上的最小结合足迹是选择独特的人类NKT TCR的基础。
J Exp Med. 2008 Apr 14;205(4):939-49. doi: 10.1084/jem.20072141. Epub 2008 Mar 31.
3
Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues.植物鞘脂类似物文库的合成及初步抗真菌活性评价
Org Biomol Chem. 2007 Dec 7;5(23):3769-77. doi: 10.1039/b709421c. Epub 2007 Oct 8.
4
NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice.在易感小鼠中，铜绿假单胞菌眼部感染后，自然杀伤T细胞对于启动炎症反应至关重要。
J Immunol. 2007 Jul 15;179(2):1138-46. doi: 10.4049/jimmunol.179.2.1138.
5
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.半不变自然杀伤T细胞受体对CD1d-脂质抗原的识别
Nature. 2007 Jul 5;448(7149):44-9. doi: 10.1038/nature05907. Epub 2007 Jun 20.
6
Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator.用一种新型的偏向Th2细胞因子的NKT细胞激活剂治疗的NOD小鼠预后改善。
J Immunol. 2007 Feb 1;178(3):1415-25. doi: 10.4049/jimmunol.178.3.1415.
7
Mechanistic studies and methods to prevent aglycon transfer of thioglycosides.硫代糖苷苷元转移的机制研究及预防方法。
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8
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.自然杀伤T细胞识别来自致病细菌的二酰基甘油抗原。
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9
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d.自然杀伤T细胞激活剂的设计：与小鼠CD1d结合的微生物糖鞘脂的结构与功能
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):3972-7. doi: 10.1073/pnas.0600285103. Epub 2006 Mar 6.
10
Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.CD1d 限制性 NKT 细胞受体的保守和异质性脂质抗原特异性
J Immunol. 2006 Mar 15;176(6):3625-34. doi: 10.4049/jimmunol.176.6.3625.

3' 和 4' 羟基在 alpha-半乳糖神经酰胺刺激不变自然杀伤 T 细胞中的作用。

The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells.

机构信息

Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.

出版信息

ChemMedChem. 2009 Nov;4(11):1810-5. doi: 10.1002/cmdc.200900350.

DOI:10.1002/cmdc.200900350
PMID:19780098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3517047/
Abstract

The marine-derived α-galactosylceramide is an exogenous ligand for natural killer T cells and leads to the secretion of both T help 1 (Th1) and Th2 cytokines. The relationship between the sugar moiety structure and invariant natural killer T (iNKT) cell stimulation ability has not been fully understood. With the series α-galactosylceramide analogues varied on C3′ and C4′ position, subjected to a murine system, we discovered that the 3′ hydroxyl is very crucial in maintaining the molecule’s immunogenicity. Any modification on this position will lead to the losing of activity. We also found that the C4′ position is not so sensitive and can tolerate some small modifications on it. Moreover, the C4′ substituted analogues induced biased Th2 cytokines release was observed.

摘要

海洋来源的α-半乳糖神经酰胺是自然杀伤 T 细胞的外源性配体，导致 T 辅助 1（Th1）和 Th2 细胞因子的分泌。糖部分结构与不变自然杀伤 T（iNKT）细胞刺激能力之间的关系尚未完全阐明。我们用一系列在 C3'和 C4'位变化的α-半乳糖神经酰胺类似物，在小鼠系统中进行研究，发现 3'羟基对于保持分子的免疫原性非常重要。该位置的任何修饰都会导致活性丧失。我们还发现 C4'位不那么敏感，可以容忍一些小的修饰。此外，观察到 C4'取代的类似物诱导偏向性 Th2 细胞因子释放。