Schwartz B, Facklam R R, Breiman R F
Respiratory Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333.
Lancet. 1990 Nov 10;336(8724):1167-71. doi: 10.1016/0140-6736(90)92777-f.
To see whether changes in the epidemiology of group A streptococcal disease in the USA have been accompanied by a corresponding change in serotype distribution, epidemiological and M-typing and T-typing data for 5193 strains sent to the Centers for Disease Control, Atlanta, between 1972 and 1988 were analysed. The proportions of M-types 1, 3, and 18 increased significantly during the study period. These M-types were more likely to be invasive, to cause fatal infection, and to occur in a cluster of infections than were other types. By contrast, the proportions of M-types 4 and 12 decreased; they were less invasive and were less likely to be found in clusters than were other types. These data suggest that changes in the epidemiology of group A streptococcal disease may be related to changes in the distribution of M-types causing infection.
为了观察美国A组链球菌疾病流行病学的变化是否伴随着血清型分布的相应改变，对1972年至1988年间送往亚特兰大疾病控制中心的5193株菌株的流行病学、M分型和T分型数据进行了分析。在研究期间，M1型、M3型和M18型的比例显著增加。与其他类型相比，这些M型更有可能具有侵袭性、导致致命感染并在感染群中出现。相比之下，M4型和M12型的比例下降；与其他类型相比，它们的侵袭性较小，在感染群中出现的可能性也较小。这些数据表明，A组链球菌疾病流行病学的变化可能与引起感染的M型分布变化有关。
