Mwanakasale Victor, Siziya Seter, Mwansa James, Koukounari Artemis, Fenwick Alan
Tropical Diseases Research Centre, P.O. Box 71769, Ndola, Zambia.
Malawi Med J. 2009 Mar;21(1):12-8. doi: 10.4314/mmj.v21i1.10982.
To study impact of once weekly iron supplementation on praziquantel cure rate, Schistosoma haematobium reinfection, and haematological parameters in pupils aged between 9 and 15 years of age in Nchelenge district, Zambia.
Pupils in the intervention group received once weekly dose of ferrous sulphate at 200 mg while those in the control received once weekly vitamin C at 100 mg for up to 9 months. Both study groups received a single dose of praziquantel at baseline.
S haematobium reinfection intensity was significantly lower in boys in the intervention group than in boys in the control group at 6 months (P < 0.001) and 9 months (P < 0.001) of supplementation. Significantly lower S haematobium reinfection intensity was found in girls in the intervention group than in girls in the control group only at 6 months of supplementation (P = 0.018). Boys in the intervention group were 42% (Adjusted Risk Ratio = 0.58, 95% confidence interval 0.39, 0.86) less likely to be reinfected with S haematobium than in the control group at 6 months follow up.
Once weekly iron supplementation can decrease S haematobium reinfection after 6 months and should be incorporated into school based schistosomiasis control programs in highly endemic areas.
研究每周一次补充铁剂对赞比亚恩切伦格区9至15岁小学生吡喹酮治愈率、埃及血吸虫再感染及血液学参数的影响。
干预组学生每周服用一次200毫克硫酸亚铁，对照组学生每周服用一次100毫克维生素C，持续9个月。两个研究组在基线时均接受单剂量吡喹酮治疗。
在补充铁剂6个月（P<0.001）和9个月（P<0.001）时，干预组男孩的埃及血吸虫再感染强度显著低于对照组男孩。仅在补充铁剂6个月时，干预组女孩的埃及血吸虫再感染强度显著低于对照组女孩（P=0.018）。在6个月随访时，干预组男孩感染埃及血吸虫的可能性比对照组低42%（调整风险比=0.58，95%置信区间0.39，0.86）。
每周一次补充铁剂可在6个月后降低埃及血吸虫再感染率，应纳入高流行地区基于学校的血吸虫病控制项目。
