a Área de Medicina Preventiva y Salud Pública, Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Toxicología y Medicina Legal, Facultad de Farmacia , Universitat de Valencia , Burjasot, Valencia , Spain.
b CIBER de Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.
Pathog Glob Health. 2019 May;113(3):101-108. doi: 10.1080/20477724.2019.1603902. Epub 2019 Apr 14.
Schistosomiasis is a parasitic disease caused by helminths of the genus with two presentations; one intestinal and another urinary; which depend on the specie of . One of the species that can produce intestinal schistosomiasis is , and the specie that produces urinary schistosomiasis is . Infection can be aggravated by a deficient nutritional status, which negatively impacts the immune system and increases susceptibility to infection. The main objective of this meta-analysis is to determine if a relationship exists between multimicronutrient supplementation and the reduction of infestation with and in children and adolescents. A search was conducted through a scientific literature database, and articles that complied with the pre-established requirements were retrieved. The Review Manager (Rev Man) 5.3 computer program was used for data processing and analysis was carried out with the objective of testing whether the addition of micronutrient supplementation to treatment with broad-spectrum antiparasitic anthelmintic medication has an impact on schistosomiasis infection. Of the 257 initial articles retrieved, eight were included both quantitatively and qualitatively in the meta-analysis. Supplementation reduces infestation with 1.33 times more than placebo. In individuals infested with supplementation is 1.30 times more effective than placebo and for individuals infested with , supplementation is 1.62 times more effective than the placebo. The results show a clear relationship between supplementation and reduction of infestation. The supplementation with micronutrients decreases the presence of in children and adolescents.
血吸虫病是一种由 属寄生虫引起的寄生虫病，有两种表现形式；一种是肠道的，另一种是尿路的；这取决于 的种类。能引起肠道血吸虫病的一种物种是 ，而引起尿路血吸虫病的物种是 。感染会因营养不良而加重，这会对免疫系统产生负面影响，并增加感染的易感性。本荟萃分析的主要目的是确定多种微量营养素补充是否与减少儿童和青少年感染 和 之间存在关系。通过科学文献数据库进行了搜索，并检索了符合预先确定要求的文章。使用 Review Manager (Rev Man) 5.3 计算机程序进行数据处理和分析，目的是测试在广谱抗寄生虫驱虫药物治疗中添加微量营养素补充是否对血吸虫病感染有影响。在最初检索到的 257 篇文章中，有 8 篇在定量和定性上都被纳入了荟萃分析。补充剂比安慰剂更能减少 1.33 倍的感染。在感染 的个体中，补充剂比安慰剂有效 1.30 倍，而在感染 的个体中，补充剂比安慰剂有效 1.62 倍。结果表明，补充剂与减少感染之间存在明显的关系。微量营养素的补充减少了儿童和青少年中 的存在。
