Discipline of General Pathology, Biological Sciences Department, Triângulo Mineiro Federal University, Uberaba, Minas Gerais State, Brazil.
Diagn Pathol. 2009 Sep 25;4:33. doi: 10.1186/1746-1596-4-33.
We are reporting the first collagenofibrotic glomerulopathy (CG) in South America. So, this collagen type III glomerulopathy is not limited to Japan but may be found throughout the world.
We describe three patients that presented some factors in common, such as sex, age and the presence of non-nephrotic proteinuria associated with microscopic hematuria. The findings with the immunofluorescence microscopy, of immunoglobulins, and components of the complement were usually negative. The picrosyrius staining showed the presence of reddish material in the mesangium, when it was seen under standard microscopy; however, when it was seen with birefringence, it became greenish under polarized light, showed the collagen found in this area of the glomerulus. The identification of CG was made through electronic microscopic scanning, and curved and disorganized fibers were found.
These cases are the first from South America to be reported, and they are about an idiopathic renal disease that is not related to any specific races or locations. The reports contribute to a better understanding of this disease, which although not so prevalent, should be considered as an importantly differential diagnostic of cases of proteinuria.
我们报告了在南美的首例胶原纤维性肾小球病（CG）。因此，这种胶原 III 型肾小球病不仅局限于日本，可能在世界各地都有发现。
我们描述了 3 名患者，他们有一些共同的特征，如性别、年龄和存在非肾病性蛋白尿伴镜下血尿。免疫荧光显微镜检查发现免疫球蛋白和补体成分通常为阴性。皮罗西斯染色显示在标准显微镜下，肾小球系膜中存在红色物质；然而，当用偏光显微镜观察时，它在偏振光下变成绿色，显示出在肾小球这一区域发现的胶原。通过电子显微镜扫描来识别 CG，发现了弯曲和紊乱的纤维。
这些病例是南美的首例报告，是一种特发性肾脏疾病，与任何特定种族或地理位置无关。这些报告有助于更好地了解这种疾病，尽管它并不常见，但应被视为蛋白尿病例的重要鉴别诊断之一。
