Gibson I W, More I A
University Department of Pathology, Western Infirmary, Glasgow, U.K.
J Pathol. 1998 Feb;184(2):123-9. doi: 10.1002/(SICI)1096-9896(199802)184:2<123::AID-PATH16>3.0.CO;2-X.
The last decade has seen significant advances in the fields of cellular and molecular biology and pathology. These have contributed to our understanding of the mechanisms of glomerular disease and indicate possible novel approaches to therapy. This review discusses recent insights into the pathogenesis of glomerular disease, with consideration of the roles of intrinsic glomerular cells, infiltrating inflammatory cells, circulating permeability factors, and antibodies, and recent advances in the molecular pathology of the glomerular basement membrane. Changes in the perception of some well-established glomerular entities such as focal segmental glomerulosclerosis are considered. In addition, a number of newly-recognized specific glomerulopathies including collapsing glomerulopathy, fibrillary and immunotactoid glomerulopathy, fibronectin glomerulopathy, and collagenofibrotic glomerulopathy are briefly reviewed.
过去十年，细胞与分子生物学及病理学领域取得了重大进展。这些进展有助于我们理解肾小球疾病的发病机制，并指出了可能的新型治疗方法。本综述讨论了肾小球疾病发病机制的最新见解，考虑了肾小球固有细胞、浸润性炎症细胞、循环通透性因子和抗体的作用，以及肾小球基底膜分子病理学的最新进展。文中还探讨了对一些已确立的肾小球疾病实体（如局灶节段性肾小球硬化症）认识的变化。此外，还简要回顾了一些新认识的特定肾小球病，包括塌陷性肾小球病、纤维样和免疫触须样肾小球病、纤维连接蛋白肾小球病和胶原纤维性肾小球病。
