Zhejiang-California International Nanosystems Institute Molecular Imaging Platform, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, PR China.
Int J Pharm. 2010 Jan 15;384(1-2):148-53. doi: 10.1016/j.ijpharm.2009.09.027. Epub 2009 Sep 23.
Echogenic bubble formulations have wide applications in both disease diagnosis and therapy. In the current study, nanobubbles were prepared and the contrast agent function was evaluated in order to study the nanosized bubble's property for ultrasonic imaging. Coumarin-6 as a model drug was loaded into nanobubbles to investigate the drug delivery potential to cells. The results showed that the nanobubbles composed of 1% of Tween 80, and 3 mg/ml of lipid worked well as an ultrasonic contrast agent by presenting a contrast effect in the liver region in vivo. The drug-loaded nanobubbles could enhance drug delivery to cells significantly, and the process was analyzed by sigmoidally fitting the pharmacokinetic curve. It can be concluded that the nanobubble formulation is a promising approach for both ultrasound imaging and drug delivery enhancing.
声振微泡制剂在疾病诊断和治疗中具有广泛的应用。本研究制备了纳米气泡，并评估了其作为对比剂的功能，旨在研究纳米气泡在超声成像中的特性。香豆素-6 被用作模型药物载入纳米气泡中，以研究其向细胞递药的潜力。结果表明，由 1%的 Tween 80 和 3mg/ml 的脂质组成的纳米气泡作为超声对比剂在体内肝脏区域呈现出良好的对比效果。载药纳米气泡可以显著增强药物向细胞的递药，并且通过对药代动力学曲线进行 sigmoidal 拟合来分析该过程。可以得出结论，纳米气泡制剂是一种很有前途的超声成像和药物递送增强方法。
