Jayasankar Gokulnath, Koilpillai Jebastin, Narayanasamy Damodharan
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institution of Science and Technology, Kattankulathur, Chengalpattu, India.
Adv Pharm Bull. 2024 Jul;14(2):278-301. doi: 10.34172/apb.2024.042. Epub 2024 Mar 17.
Delivery of diagnostic drugs via nanobubbles (NBs) has shown to be an emerging field of study. Due to their small size, NBs may more easily travel through constricted blood vessels and precisely target certain bodily parts. NB is considered the major treatment for cancer treatment and other diseases which are difficult to diagnose. The field of NBs is dynamic and continues to grow as researchers discover new properties and seek practical applications in various fields. The predominant usage of NBs in novel drug delivery is to enhance the bioavailability, and controlled drug release along with imaging properties NBs are important because they may change interfacial characteristics including surface force, lubrication, and absorption. The quick diffusion of gas into the water was caused by a hypothetical film that was stimulated and punctured by a strong acting force at the gas/water contact of the bubble. In this article, various prominent aspects of NBs have been discussed, along with the long-acting nature, and the theranostical aspect which elucidates the potential marketed drugs along with clinical trial products. The article also covers quality by design aspects, different production techniques that enable method-specific therapeutic applications, increasing the floating time of the bubble, and refining its properties to enhance the prepared NB's quality. NB containing both analysis and curing properties makes it special from other nano-carriers. This work includes all the possible methods of preparing NB, its application, all marketed drugs, and products in clinical trials.
通过纳米气泡（NBs）递送诊断药物已成为一个新兴的研究领域。由于其尺寸小，纳米气泡可能更容易穿过狭窄的血管并精确靶向身体的某些部位。纳米气泡被认为是癌症治疗和其他难以诊断的疾病的主要治疗方法。随着研究人员发现纳米气泡的新特性并在各个领域寻求实际应用，纳米气泡领域充满活力且不断发展。纳米气泡在新型药物递送中的主要用途是提高生物利用度，以及控制药物释放，同时其成像特性也很重要，因为它们可能会改变界面特性，包括表面力、润滑和吸收。气体在水中的快速扩散是由一种假设的薄膜引起的，该薄膜在气泡的气/水接触处受到强大作用力的刺激和刺穿。在本文中，讨论了纳米气泡的各个突出方面，以及其长效性质和诊疗方面，后者阐明了潜在的上市药物以及临床试验产品。本文还涵盖了设计质量方面、能够实现特定方法治疗应用的不同生产技术、增加气泡的漂浮时间以及改善其性质以提高制备的纳米气泡质量。兼具分析和治疗特性的纳米气泡使其有别于其他纳米载体。这项工作包括制备纳米气泡的所有可能方法、其应用、所有上市药物以及临床试验中的产品。
