Wang Xin, Tu Mengqi, Yan Kai, Li Penghui, Pang Long, Gong Ying, Li Qing, Liu Ruiqing, Xu Zushun, Xu Haibo, Chu Paul K
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030, China.
ACS Appl Mater Interfaces. 2015 Nov 11;7(44):24523-32. doi: 10.1021/acsami.5b08802. Epub 2015 Oct 29.
In this study, a novel polymerizable CT contrast agent integrating iodine with europium(III) has been developed by a facile and universal coordination chemistry method. The Fe3O4 nanoparticles are then incorporated into this iodine-containing europium complex by seed-emulsifier-free polymerization. The nanocomposites combining the difunctional complex and superparamagnetic Fe3O4 nanoparticles, which have uniform size dispersion and high encapsulation rate, are suitable for computed X-ray tomography (CT), magnetic resonance imaging (MRI), and optical imaging. They possess good paramagnetic properties with a maximum saturation magnetization of 2.16 emu/g and a transverse relaxivity rate of 260 mM(-1) s(-1), and they exhibit obvious contrast effects with an iodine payload less than 4.8 mg I/mL. In the in vivo optical imaging assessment, vivid fluorescent dots can be observed in the liver and spleen by two-photon confocal scanning laser microscopy (CLSM). All the results showed that nanocomposites as polymeric trifunctional contrast agents have great clinical potential in CT, MR, and optical imaging.
在本研究中，通过一种简便通用的配位化学方法，开发了一种将碘与铕（III）整合的新型可聚合CT造影剂。然后通过无种子乳化剂聚合将Fe3O4纳米颗粒掺入这种含碘铕配合物中。结合双功能配合物和超顺磁性Fe3O4纳米颗粒的纳米复合材料具有均匀的尺寸分散性和高封装率，适用于计算机X射线断层扫描（CT）、磁共振成像（MRI）和光学成像。它们具有良好的顺磁性能，最大饱和磁化强度为2.16 emu/g，横向弛豫率为260 mM(-1) s(-1)，并且在碘负载量小于4.8 mg I/mL时表现出明显的对比效果。在体内光学成像评估中，通过双光子共聚焦扫描激光显微镜（CLSM）可以在肝脏和脾脏中观察到清晰的荧光点。所有结果表明，作为聚合物三功能造影剂的纳米复合材料在CT、MR和光学成像方面具有巨大的临床潜力。
