感染伊氏锥虫对实验感染猫血液、血浆和脑组织中胆碱酯酶的影响。
Influence of Trypanosoma evansi in blood, plasma, and brain cholinesterase of experimentally infected cats.
机构信息
Universidade Federal de Santa Maria, Faixa de Camobi, Km 9, Campus Universitário, 97105-900 Santa Maria, RS, Brazil.
出版信息
Res Vet Sci. 2010 Apr;88(2):281-4. doi: 10.1016/j.rvsc.2009.08.011. Epub 2009 Sep 24.
Changes in blood, plasma and brain cholinesterase activities in Trypanosoma evansi-infected cats were investigated. Seven animals were infected with 10(8) trypomastigote forms each and six were used as control. Animals were monitored for 56 days by examining daily blood smears. Blood samples were collected at days 28 and 56 post-inoculation to determine the activity of acetylcholinesterase (AChE) in blood and the activity of butyrylcholinesterase (BChE) in plasma. AChE was also evaluated in total brain. The activity of AChE in blood and brain, and the activity of BChE in plasma significantly reduced in the infected cats. Therefore, the infection by T. evansi influenced cholinesterases of felines indicating changes in the responses of the cholinergic system.
研究了感染伊氏锥虫的猫血液、血浆和脑组织中胆碱酯酶活性的变化。将 7 只动物感染 10（8）个锥虫型滋养体，6 只作为对照。通过每天检查血涂片监测动物 56 天。在接种后第 28 天和第 56 天收集血液样本，以确定血液中乙酰胆碱酯酶（AChE）和血浆中丁酰胆碱酯酶（BChE）的活性。还评估了大脑中的 AChE。感染猫血液和大脑中的 AChE 以及血浆中的 BChE 活性显著降低。因此，T. evansi 的感染影响了猫的胆碱酯酶，表明胆碱能系统的反应发生了变化。
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