Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Acad Radiol. 2009 Dec;16(12):1493-501. doi: 10.1016/j.acra.2009.07.025. Epub 2009 Sep 24.
The objective of this study was to determine how metabolite values (total N-acetyl aspartate [tNAA], glutamate plus glutamine [Glx], total choline [tCho], myoinositol [mI], and total creatine [tCr]) vary across brain regions in healthy subjects. This study was implemented to create an internal reference database for patients with psychiatric disorders and epilepsy.
Using the multivoxel technique with a voxelwise phantom calibration on a 3-T magnetic resonance imaging scanner, metabolite levels of 29 healthy controls (13 men, 16 women; average age, 29 years) were obtained from the hippocampi, basal ganglia, insula cortex, cingulum, and precuneus. Additionally, gray and white matter metabolite values were obtained from the frontal and parietal lobes.
No significant effect of gender was noticed. The total magnitude of variation was greatest for Glx, followed by tNAA, mI, tCho, and tCr. Glx/tCr, Glx, and tCr were increased in gray matter, while tNAA/tCr, tCho/tCr, respectively tNAA and tCho, were elevated in white matter. These findings indicate (1) anterior-to-posterior increases of tNAA/tCr and Glx/tCr, respectively tNAA and Glx, along the midline in gray matter (cingulum); (2) increased tNAA/tCr, respectively tNAA, in white matter in the fiber tracts of the precentral region; (3) an accentuated anterior-to-posterior increase of tCr in the insula cortex; and (4) an anterior-to-posterior decrease of tCho/tCr and tCho in white matter.
There are significant metabolic differences within tissue types and within tissue types at different locations; therefore, the spectra and metabolite values presented should provide a useful internal reference for both clinical and research studies.
本研究旨在确定健康受试者大脑不同区域的代谢物值（总 N-乙酰天冬氨酸 [tNAA]、谷氨酸加谷氨酰胺 [Glx]、总胆碱 [tCho]、肌醇 [mI] 和总肌酸 [tCr]）如何变化。该研究旨在为精神障碍和癫痫患者创建内部参考数据库。
使用多体素技术和 3T 磁共振成像扫描仪上的体素幻影校准，从 29 名健康对照者（13 名男性，16 名女性；平均年龄 29 岁）的海马体、基底节、脑岛皮质、扣带回和楔前叶获得代谢物水平。此外，还从额叶和顶叶获得灰质和白质代谢物值。
未发现性别对结果有显著影响。总变异性最大的是 Glx，其次是 tNAA、mI、tCho 和 tCr。Glx/tCr、Glx 和 tCr 在灰质中增加，而 tNAA/tCr、tCho/tCr 和 tCho 分别在白质中增加。这些发现表明 (1) 中线灰质（扣带回）中 tNAA/tCr 和 Glx/tCr （分别是 tNAA 和 Glx）从前向后增加；(2) 中央前回纤维束白质中 tNAA/tCr （分别是 tNAA）增加；(3) 脑岛皮质 tCr 从前向后增加明显；(4) 白质中 tCho/tCr 和 tCho 从前向后减少。
组织类型内和组织类型不同部位之间存在显著的代谢差异；因此，所呈现的谱和代谢物值应为临床和研究提供有用的内部参考。
