Choi Sooyoung, Song Yumi, Lee Kija, Lee Youngwon, Choi Hojung
Ian Animal Diagnostic Center, Seoul 06014, Korea.
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
J Vet Sci. 2016 Jun 30;17(2):217-24. doi: 10.4142/jvs.2016.17.2.217.
This study was conducted to measure the difference in levels of cerebral metabolites in the right and left hemispheres, gray (GM) and white matter (WM), imaging planes, and anatomical regions of healthy dogs to establish normal variations. Eight male Beagle dogs (1 to 4 years of age; mean age, 2 years) with no evidence of neurologic disease were studied. Using the multi-voxel technique on a 1.5 Tesla magnetic resonance imaging scanner, metabolite values (N-acetyl aspartate [NAA], choline [Cho], creatine [Cr]) were obtained from the frontoparietal WM, parietal GM, temporal GM, occipital GM, thalamus, cerebellum, mid-brain, and pons. There was no significant difference in levels of these metabolites between the right and left in any locations or between the GM and WM in the cerebral hemispheres. However, there were significant differences in metabolite ratios within imaging planes. The NAA/Cr was lower in the cerebellum than other regions and the thalamus had a higher Cho/Cr and lower NAA/Cho ratio than in other regions. The spectral and metabolic values will provide a useful internal reference for clinical practice and research involving multi-voxel magnetic resonance spectroscopy. Measurement of metabolite values in the transverse plane is recommended for comparing levels of regional metabolites.
本研究旨在测量健康犬左右半球、灰质（GM）和白质（WM）、成像平面以及解剖区域中脑代谢物水平的差异，以确定正常变异情况。研究了8只无神经疾病迹象的雄性比格犬（1至4岁；平均年龄2岁）。在1.5特斯拉磁共振成像扫描仪上使用多体素技术，从前顶叶白质、顶叶灰质、颞叶灰质、枕叶灰质、丘脑、小脑、中脑和脑桥获取代谢物值（N-乙酰天门冬氨酸 [NAA]、胆碱 [Cho]、肌酸 [Cr]）。在任何位置，这些代谢物的水平在左右之间或大脑半球的灰质和白质之间均无显著差异。然而，成像平面内的代谢物比率存在显著差异。小脑中的NAA/Cr低于其他区域，丘脑中的Cho/Cr高于其他区域，NAA/Cho低于其他区域。光谱和代谢值将为涉及多体素磁共振波谱的临床实践和研究提供有用的内部参考。建议在横断面测量代谢物值以比较区域代谢物水平。
