mir-210：肿瘤发生过程中低氧应激的传感器。
mir-210: a sensor for hypoxic stress during tumorigenesis.
作者信息
Mathew Lijoy K, Simon M Celeste
机构信息
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Mol Cell. 2009 Sep 24;35(6):737-8. doi: 10.1016/j.molcel.2009.09.008.
Abstract
In this issue of Molecular Cell, Huang et al. (2009) demonstrate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibiting tumor initiation.
摘要
在本期《分子细胞》杂志中，黄等人（2009年）证明，缺氧诱导的mir-210通过抑制肿瘤起始，作为细胞适应和存活的变阻器。
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本文引用的文献
1
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Mol Cell. 2009 Sep 24;35(6):856-67. doi: 10.1016/j.molcel.2009.09.006.
2
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.微小RNA miR-210通过MYC拮抗剂MNT调节细胞对缺氧的反应。
Cell Cycle. 2009 Sep 1;8(17):2756-68. doi: 10.4161/cc.8.17.9387. Epub 2009 Sep 29.
3
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.治疗性微小RNA递送可抑制小鼠肝癌模型中的肿瘤发生。
Cell. 2009 Jun 12;137(6):1005-17. doi: 10.1016/j.cell.2009.04.021.
4
MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.微小RNA-210调节内皮细胞对缺氧的反应并抑制受体酪氨酸激酶配体Ephrin-A3。
J Biol Chem. 2008 Jun 6;283(23):15878-83. doi: 10.1074/jbc.M800731200. Epub 2008 Apr 16.
5
Hypoxia-inducible factors, stem cells, and cancer.缺氧诱导因子、干细胞与癌症。
Cell. 2007 May 4;129(3):465-72. doi: 10.1016/j.cell.2007.04.019.
6
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.缺氧诱导因子-2α通过增强c-myc转录活性促进缺氧细胞增殖。
Cancer Cell. 2007 Apr;11(4):335-47. doi: 10.1016/j.ccr.2007.02.006.
7
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Nat Cell Biol. 2007 Feb;9(2):210-7. doi: 10.1038/ncb1534. Epub 2007 Jan 14.
8
A microRNA signature of hypoxia.缺氧的微小RNA特征
Mol Cell Biol. 2007 Mar;27(5):1859-67. doi: 10.1128/MCB.01395-06. Epub 2006 Dec 28.
9
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Oncogene. 2006 Oct 9;25(46):6170-5. doi: 10.1038/sj.onc.1209911.
10
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EMBO J. 2004 May 5;23(9):1949-56. doi: 10.1038/sj.emboj.7600196. Epub 2004 Apr 8.
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