Wu Ligang, Belasco Joel G
Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Mol Cell. 2008 Jan 18;29(1):1-7. doi: 10.1016/j.molcel.2007.12.010.
The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.
微小RNA（miRNA）和小干扰RNA（siRNA）介导的基因表达下调是一个复杂的过程，涉及翻译抑制和mRNA周转加速，而这两种情况似乎都是通过多种机制发生的。此外，在某些条件下，miRNA也能够激活翻译。多种细胞蛋白参与了这些调控机制，但其确切作用仍大多未得到解决。
