Jenkins M A, Hurley S F, Bowes G, McNeil J J
Department of Social and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Vic.
Med J Aust. 1990 Sep 17;153(6):323-8. doi: 10.5694/j.1326-5377.1990.tb136939.x.
Bronchodilator prescription and sales data for Australia from 1975 to 1986 were analysed. Inhaled beta-agonists were the most commonly prescribed antiasthmatic agents in 1986, followed by sustained-release theophylline and inhaled corticosteroids. Marked increases in prescription sales of these three drug groups over the period were noted. We estimate that non-prescription sales of salbutamol inhalers increased by 410% between 1980 and 1986 (P less than 0.01). Prescribing rates by general practitioners for beta-agonists, sustained-release theophylline and inhaled corticosteroids increased from 1979 to 1986. Prescribing rates of beta-agonists were highest for persons aged 1-11 years and 55 years and over, and increased markedly for children aged 1-11 years over the period. For sustained-release theophylline, prescribing rates were highest for persons 55 years and over. The difficulties in postulating possible relationships between prescribing trends and asthma mortality are discussed.
对1975年至1986年澳大利亚支气管扩张剂的处方和销售数据进行了分析。1986年,吸入型β受体激动剂是最常用的抗哮喘药物,其次是缓释茶碱和吸入型皮质类固醇。在此期间,这三类药物的处方销售量显著增加。我们估计,1980年至1986年期间,沙丁胺醇吸入器的非处方销售量增长了410%(P<0.01)。1979年至1986年,全科医生对β受体激动剂、缓释茶碱和吸入型皮质类固醇的处方率有所上升。β受体激动剂的处方率在1至11岁以及55岁及以上人群中最高,且在此期间1至11岁儿童的处方率显著上升。对于缓释茶碱,55岁及以上人群的处方率最高。讨论了推测处方趋势与哮喘死亡率之间可能关系的困难。