Diamond Ivan R, Pencharz Paul B, Wales Paul W
Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, Canada.
Semin Pediatr Surg. 2009 Nov;18(4):239-45. doi: 10.1053/j.sempedsurg.2009.07.005.
Intestinal failure associated liver disease (IFALD) is one of the most common and devastating complications in infants with intestinal failure. Although multifactorial, its pathophysiology is clearly related to the administration of parenteral nutrition (PN), with a recent focus on the role of PN lipid emulsions. This paper will review the evidence for the use of omega-3 fatty acid PN lipid emulsions, which are proposed to have efficacy in the treatment of IFALD. Mechanisms explaining their effects will be considered as will future research directions.
肠衰竭相关肝病（IFALD）是肠衰竭婴儿中最常见且极具破坏性的并发症之一。尽管其病因是多因素的，但其病理生理学显然与肠外营养（PN）的使用有关，近期重点关注PN脂质乳剂的作用。本文将综述使用ω-3脂肪酸PN脂质乳剂的证据，该脂质乳剂被认为对治疗IFALD有效。将探讨解释其作用的机制以及未来的研究方向。
