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两名不可逆性肠衰竭患者在使用 ω-3 脂肪酸脂质乳剂治疗期间，门静脉纤维化未能得到解决。

Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure.

机构信息

Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children's Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045, USA.

出版信息

J Pediatr. 2010 Feb;156(2):327-31. doi: 10.1016/j.jpeds.2009.08.033.

DOI:10.1016/j.jpeds.2009.08.033
PMID:20105644
Abstract

Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.

摘要

肠外ω-3 脂肪酸脂质乳剂已被评估用于逆转肠衰竭相关肝病的潜在作用。我们报告了使用 Omegaven 治疗 2 例不可逆性肠衰竭和肠衰竭相关肝病患者的经验。尽管胆汁淤积的生化和组织学改善，但肝活检显示这 2 例患者均存在持续存在的显著门脉纤维化。

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