Hotta Ryo, Natarajan Dipa, Thapar Nikhil
Department of Anatomy & Cell Biology, University of Melbourne, Victoria, Australia.
Semin Pediatr Surg. 2009 Nov;18(4):263-73. doi: 10.1053/j.sempedsurg.2009.07.008.
Gut motility disorders represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with stem cells to restore missing or defective elements of the gut neuromusculature offers new hope for potential cure. Focusing on enteric neuropathies such as Hirschsprung's disease, the review discusses the progress that has been made in the sourcing of putative stem cells and the studies into their biology and therapeutic potential. It also explores the practical challenges that must be overcome before stem cell-based therapies can be applied in the clinical arena. Although many obstacles remain, the speed of advancement of the enteric stem cell field suggests that such therapies are on the horizon.
肠道动力障碍在临床管理中是一项重大挑战，当前的姑息治疗方法未能克服疾病及与治疗相关的发病率问题。干细胞在恢复肠道神经肌肉系统缺失或有缺陷的成分方面取得的最新进展为潜在治愈带来了新希望。本文聚焦于诸如先天性巨结肠等肠道神经病变，讨论了在寻找假定干细胞来源方面取得的进展以及对其生物学特性和治疗潜力的研究。它还探讨了在基于干细胞的疗法能够应用于临床领域之前必须克服的实际挑战。尽管仍然存在许多障碍，但肠道干细胞领域的进展速度表明此类疗法即将出现。
