Dafopoulos Konstantinos, Sourlas Dimitrios, Kallitsaris Athanasios, Pournaras Spyros, Messinis Ioannis E
Department of Obstetrics and Gynecology, University of Thessalia, Larissa, Greece.
Department of Microbiology, University of Thessalia, Larissa, Greece.
Fertil Steril. 2009 Oct;92(4):1389-1394. doi: 10.1016/j.fertnstert.2008.07.1773. Epub 2008 Sep 30.
To investigate changes of ghrelin, resistin, and adiponectin levels in the circulation during the normal menstrual cycle.
Longitudinal study.
The study was conducted at a university hospital.
PATIENT(S): Eight healthy normally cycling women.
INTERVENTION(S): The women were observed during a whole menstrual cycle. Daily blood samples were taken every morning, after overnight fasting, from day 2 of the cycle until the next menstrual period.
MAIN OUTCOME MEASURE(S): Plasma acylated and unacylated ghrelin and serum resistin, adiponectin, FSH, LH, E(2), and P levels were measured in all blood samples.
RESULT(S): In all women serum FSH, LH, E(2), and P levels, normalized to the midcycle peak LH value, showed the typical changes of the normal menstrual cycle. Acylated and unacylated ghrelin, resistin, and adiponectin levels did not change significantly during the whole menstrual cycle.
CONCLUSION(S): The present study shows for the first time that plasma ghrelin and serum resistin levels do not change significantly during the normal menstrual cycle. It is also confirmed that serum adiponectin levels remain stable throughout the cycle. It is suggested that ovarian steroid dynamics during the cycle have no effect on the secretion of these substances.
研究正常月经周期中循环血中胃饥饿素、抵抗素和脂联素水平的变化。
纵向研究。
研究在一家大学医院进行。
8名月经周期正常的健康女性。
对这些女性进行了一个完整月经周期的观察。从月经周期第2天开始，每天早晨空腹采血，直至下次月经来潮。
检测所有血样中的血浆酰化和去酰化胃饥饿素以及血清抵抗素、脂联素、促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇（E₂）和孕酮（P）水平。
在所有女性中，以周期中期LH峰值为标准进行标准化后的血清FSH、LH、E₂和P水平呈现出正常月经周期的典型变化。在整个月经周期中，酰化和去酰化胃饥饿素、抵抗素和脂联素水平无显著变化。
本研究首次表明，在正常月经周期中血浆胃饥饿素和血清抵抗素水平无显著变化。同时也证实血清脂联素水平在整个周期中保持稳定。提示月经周期中的卵巢甾体激素动态变化对这些物质的分泌无影响。
