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Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation.小儿肺移植术后第一年内肺部真菌感染后死亡率增加。
J Heart Lung Transplant. 2008 Jun;27(6):655-61. doi: 10.1016/j.healun.2008.03.010. Epub 2008 Apr 24.
2
High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses.用于大规模综合检测呼吸道病毒的高通量、灵敏且准确的多重PCR-微球流式细胞术系统。
J Clin Microbiol. 2007 Aug;45(8):2626-34. doi: 10.1128/JCM.02501-06. Epub 2007 May 30.
3
Voriconazole prophylaxis in lung transplant recipients.肺移植受者的伏立康唑预防治疗
Am J Transplant. 2006 Dec;6(12):3008-16. doi: 10.1111/j.1600-6143.2006.01548.x.
4
Donor-to-host transmission of bacterial and fungal infections in lung transplantation.肺移植中细菌和真菌感染的供体向宿主传播
Am J Transplant. 2006 Jan;6(1):178-82. doi: 10.1111/j.1600-6143.2005.01145.x.
5
[Surveillance of invasive mold infections in lung transplant recipients: effect of antimycotic prophylaxis with itraconazole and voriconazole].[肺移植受者侵袭性霉菌感染的监测：伊曲康唑和伏立康唑抗真菌预防的效果]
Mycoses. 2005;48 Suppl 1:51-5. doi: 10.1111/j.1439-0507.2005.01112.x.
6
Mortality after pediatric lung transplantation: autopsies vs. clinical impression.小儿肺移植后的死亡率：尸检结果与临床诊断对比
Pediatr Pulmonol. 2004 May;37(5):413-8. doi: 10.1002/ppul.20025.
7
Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management.肺移植后曲霉感染：移植类型的临床差异及其对管理的影响。
J Heart Lung Transplant. 2003 Mar;22(3):258-66. doi: 10.1016/s1053-2498(02)00477-1.
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Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients.患有囊性纤维化的肺移植受者的曲霉感染：危险因素及与其他类型移植受者的结局比较
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9
The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants.实体器官移植受者侵袭性曲霉病的发病率及肺移植预防的意义。
Transpl Infect Dis. 2002 Dec;4(4):195-200. doi: 10.1034/j.1399-3062.2002.t01-2-02002.x.
10
Nebulized amphotericin B prophylaxis for Aspergillus infection in lung transplantation: study of risk factors.雾化两性霉素B预防肺移植受者曲霉感染：危险因素研究
J Heart Lung Transplant. 2001 Dec;20(12):1274-81. doi: 10.1016/s1053-2498(01)00364-3.

儿童肺移植受者的真菌感染：定植和侵袭性疾病。

Fungal infections in pediatric lung transplant recipients: colonization and invasive disease.

机构信息

Department of Pediatrics, Children's Hospital, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

出版信息

J Heart Lung Transplant. 2009 Nov;28(11):1226-30. doi: 10.1016/j.healun.2009.06.006. Epub 2009 Sep 26.

DOI:10.1016/j.healun.2009.06.006
PMID:19782585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2782648/
Abstract

BACKGROUND

The purpose of this study was to evaluate the epidemiology and investigate the impact of colonization and pulmonary fungal infections (PFIs).

METHODS

In this investigation we performed a retrospective analysis of 55 pediatric lung transplant recipients from 2002 to 2007 at a single institution. Associations between risk factors and time to post-transplant colonization, PFI, and other outcomes were assessed using Cox proportional hazard models.

RESULTS

Although 29 patients had positive pre-transplant colonization, 33 (60%) were colonized post-transplant and 20% (11 subjects) developed proven or probable PFI. In a multivariate model, post-transplant fungal colonization was associated with older age (hazard ratio [HR] 2.9, 95% confidence interval [CI] 1.1 to 7.6), cytomegalovirus (CMV) prophylaxis (HR 5.6, 95% CI 1.3 to 24.6) and respiratory viral infection prior to fungal colonization (HR 2.9, 95% CI 1.0 to 8.3).

CONCLUSION

Neither fungal colonization nor PFI was associated with the development of chronic allograft rejection or death.

摘要

背景

本研究旨在评估流行病学并调查定植和肺部真菌感染 (PFIs) 的影响。

方法

在这项调查中，我们对 2002 年至 2007 年在一家机构接受肺移植的 55 名儿科患者进行了回顾性分析。使用 Cox 比例风险模型评估了风险因素与移植后定植、PFI 及其他结果之间的关联。

结果

尽管 29 例患者在移植前定植阳性，但 33 例（60%）在移植后定植，20%（11 例）发生了确诊或可能的 PFI。在多变量模型中，移植后真菌定植与年龄较大（风险比 [HR] 2.9，95%置信区间 [CI] 1.1 至 7.6）、巨细胞病毒 (CMV) 预防（HR 5.6，95% CI 1.3 至 24.6）和真菌定植前呼吸道病毒感染（HR 2.9，95% CI 1.0 至 8.3）相关。

结论

真菌定植和 PFI 均与慢性移植物排斥反应或死亡的发展无关。