Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Eur J Intern Med. 2009 Oct;20(6):651-3. doi: 10.1016/j.ejim.2009.04.007. Epub 2009 May 31.
Wegener's granulomatosis (WG) is a rare granulomatous necrotizing vasculitis of small vessels, affecting vascular structures having predilection for upper airways. If untreated WG can be lethal. WG is also known to cause oral mucosal lesions. We report a case of WG that was first diagnosed on oral gingival mucosa. A 51-year old woman was referred to a specialized dentist because of consistent irritative buccal gingival hyperplasia that did not react to conservative and microbial treatment. The lesion was biopsied and the diagnosis was suggestive for WG. Patient was further referred to the Department of Rheumatology and the diagnose of WG was confirmed and treated. The oral lesions cured totally. This case emphasizes the importance to recognize the oral manifestation of WG to get proper medication as soon as possible and avoid serious systemic tissue damage.
韦格纳氏肉芽肿病(WG)是一种罕见的小血管坏死性肉芽肿性血管炎,影响具有上呼吸道偏好的血管结构。如果未经治疗,WG 可能是致命的。WG 也已知会引起口腔黏膜病变。我们报告了一例 WG 病例,该病例最初在口腔牙龈黏膜上诊断出来。一名 51 岁女性因持续的刺激性颊牙龈增生而被转介给专门的牙医,该增生对保守和微生物治疗没有反应。对病变进行了活检,诊断提示为 WG。患者进一步转至风湿病科,确诊为 WG 并进行了治疗。口腔病变完全治愈。本病例强调了认识 WG 的口腔表现的重要性,以便尽快获得适当的药物治疗,避免严重的全身组织损伤。