Holst J J, Schaffalitzky de Muckadell O B, Fahrenkrug J
Institute of Medical Physiology C, University of Copenhagen, Denmark.
Pancreas. 1990 Sep;5(5):611-4. doi: 10.1097/00006676-199009000-00018.
We studied the effect of a primed i.v. infusion of somatostatin (100 micrograms as a bolus, 0.5 micrograms x kg-1 x min-1) on pancreatic exocrine secretion in response to electrical stimulation of the vagus nerves and intra-arterial infusions of acetylcholine (0.5 mg x min-1) in anesthetized pigs (17-22 kg). In control experiments, vagus stimulation and acetylcholine increased protein secretion 31- to 80-fold and 106-fold, respectively. Somatostatin inhibited the response to vagus stimulation by more than 90%, whereas the response to acetylcholine remained unaffected. It is concluded that the inhibitory action of somatostatin on the vagally induced secretion must be due to an inhibition of the impulse transmission in the efferent parasympathetic nerves to the pancreas, and it is suggested that this mechanism contributes to the inhibitory effect of somatostatin observed with other stimuli as well.
我们研究了静脉注射负荷剂量生长抑素（100微克推注，0.5微克·千克⁻¹·分钟⁻¹）对麻醉猪（体重17 - 22千克）胰腺外分泌的影响，这些猪的胰腺外分泌是由迷走神经电刺激以及动脉内注射乙酰胆碱（0.5毫克·分钟⁻¹）引起的。在对照实验中，迷走神经刺激和乙酰胆碱分别使蛋白质分泌增加31至80倍和106倍。生长抑素抑制对迷走神经刺激的反应达90%以上，而对乙酰胆碱的反应则不受影响。结论是，生长抑素对迷走神经诱导分泌的抑制作用必定是由于抑制了胰腺传出副交感神经中的冲动传递，并且有人提出这种机制也有助于生长抑素对其他刺激所观察到的抑制作用。
