Chariot J, Roze C, Vaille C, Debray C
Gastroenterology. 1978 Nov;75(5):832-7.
The effects of somatostatin on the secretions of the exocrine pancreas were studied in anesthetized and conscious fistula rats. Somatostatin resulted in a dose-dependent decrease of basal secretion (flow, bicarbonate, protein) in conscious rats. In anesthetized rats, basal secretion was initially augmented by bolus injections of 10 to 50 microgram per kg and was subsequently decreased by venous infusions of somatostatin at 1.5 to 100 microgram.kg-1.hr-1. This inhibition, which was poorly dose dependent, was greater for protein secretion than for that of water and electrolytes. Somatostatin inhibited caerulein-stimulated protein secretion by 40 to 50% but had no effect on secretion stimulated by exogenous and endogenous secretin. Somatostatin markedly inhibited secretion stimulated by 2-deoxyglucose and by electrical stimulation of the vagus nerves in a dose-dependent fashion (protein and bicarbonate exhibited a maximal inhibition of 85%). Acetylcholine-stimulated secretion was also inhibited by somatostatin, but the maximal inhibitions observed were only 505 for protein and 60% for bicarbonate. These findings agree with the hypothesis that somatostatin infusion leads to both a decrease of acetylcholine release at nerve endings and to a direct inhibition at the level of pancreatic effector cells.
在麻醉和清醒的瘘管大鼠中研究了生长抑素对胰腺外分泌的影响。生长抑素使清醒大鼠的基础分泌（流量、碳酸氢盐、蛋白质）呈剂量依赖性降低。在麻醉大鼠中，每千克体重静脉推注10至50微克生长抑素最初会增加基础分泌，随后以1.5至100微克·千克⁻¹·小时⁻¹的速度静脉输注生长抑素会使其降低。这种抑制作用剂量依赖性较差，对蛋白质分泌的抑制作用比对水和电解质分泌的抑制作用更大。生长抑素可抑制蛙皮素刺激的蛋白质分泌40%至50%，但对外源性和内源性促胰液素刺激的分泌无影响。生长抑素以剂量依赖性方式显著抑制2-脱氧葡萄糖和迷走神经电刺激所引起的分泌（蛋白质和碳酸氢盐的最大抑制率为85%）。生长抑素也可抑制乙酰胆碱刺激的分泌，但观察到的蛋白质最大抑制率仅为50%，碳酸氢盐为60%。这些发现与以下假设一致，即输注生长抑素会导致神经末梢乙酰胆碱释放减少，并直接抑制胰腺效应细胞水平的分泌。
