Department of Medical Research, Veteran Affairs Medical Center, St. Louis, MO 63106, United States.
J Colloid Interface Sci. 2009 Dec 15;340(2):202-8. doi: 10.1016/j.jcis.2009.08.032. Epub 2009 Aug 23.
A series of highly water-soluble organo-silica nanoparticles, ranging from 2 to 10nm in diameter, were synthesized by the cohydrolysis and copolycondensation reactions. omega-methoxy(polyethyleneoxy)propyltrimethoxysilane (PEG6-9) and hydroxymethyltriethoxysilane (HMTEOS) mixtures were catalyzed by sodium hydroxide in the presence of surfactant benzethonium chloride (BTC) with various ratios of PEG6-9/HMTEOS at room temperature. The synthesized organo-silica nanoparticles possess a core-shell structure with a core of organo-silica resulting from HMTEOS and a monolayer shell of PEG6-9. The chemo-physical characteristics of the particles were studied by gel permeation chromatography (GPC), Fourier transform infrared (FTIR) spectroscopy, (29)Si nuclear magnetic resonance (NMR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The molecular weight and particle size of the particles increased with increasing HMTEOS molar ratios. The richest HMTEOS composition for the water-soluble particles was found to be HMTEOS:PEG6-9=80:20, where the particles had a 6nm diameter core and a 0.8nm thick shell. We propose that these water-soluble organo-silica nanoparticles will be suitable for biomedical applications.
一系列高度水溶性的有机硅纳米粒子，直径从 2 到 10nm 不等，是通过共水解和共缩聚反应合成的。ω-甲氧基（聚乙氧基）丙基三甲氧基硅烷（PEG6-9）和羟甲基三乙氧基硅烷（HMTEOS）混合物在表面活性剂苯扎氯铵（BTC）存在下，在氢氧化钠的催化作用下，在不同比例的 PEG6-9/HMTEOS 室温下进行反应。合成的有机硅纳米粒子具有核壳结构，核为 HMTEOS 形成的有机硅，壳为单层的 PEG6-9。通过凝胶渗透色谱（GPC）、傅里叶变换红外（FTIR）光谱、（29）Si 核磁共振（NMR）、动态光散射（DLS）、透射电子显微镜（TEM）和热重分析（TGA）研究了颗粒的化学物理特性。颗粒的分子量和粒径随 HMTEOS 摩尔比的增加而增加。水溶性颗粒的 HMTEOS 最丰富的组成被发现是 HMTEOS：PEG6-9=80:20，其中颗粒的核直径为 6nm，壳厚为 0.8nm。我们提出，这些水溶性有机硅纳米粒子将适用于生物医学应用。
