M Ways Twana Mohammed, Ng Keng Wooi, Lau Wing Man, Khutoryanskiy Vitaliy V
Reading School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UK.
College of Pharmacy, University of Sulaimani, Sulaimani 46001, Iraq.
Pharmaceutics. 2020 Aug 10;12(8):751. doi: 10.3390/pharmaceutics12080751.
Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.
经黏膜给药包括通过各种黏膜给药，如胃肠道、鼻腔、眼部和阴道黏膜。纳米颗粒在经黏膜给药中的应用具有诸多优势，包括保护药物免受黏膜腔和表面恶劣环境的影响、延长药物停留时间以及增强药物吸收。由于其制备方法相对简单、安全性良好且具有表面功能化的可能性，二氧化硅纳米颗粒在经黏膜给药方面极具前景。本综述介绍了二氧化硅纳米颗粒，并概述了各种核壳型和表面功能化二氧化硅纳米颗粒的制备方法。对二氧化硅纳米颗粒的功能与其与各种黏膜相互作用之间的关系进行了批判性分析。还讨论了二氧化硅纳米颗粒在经黏膜给药中的应用。
