Department of Neurology and Brain Research Unit, Clinical Research Centre/Mediteknia, University Hospital and University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland.
Neurobiol Aging. 2011 Mar;32(3):547.e7-9. doi: 10.1016/j.neurobiolaging.2009.08.010. Epub 2009 Sep 23.
High temperature requirement 1 (HTRA1) gene is a plausible risk factor in Alzheimer's disease (AD) as it encodes a protease known to degrade amyloid-β peptide. Here we have studied whether single nucleotide polymorphisms (SNPs) in the HTRA1 gene or its nearby regions associated with AD in a large clinic-based case-control cohort originating from Finland. We did not observe significant association of the HTRA1 SNPs with AD among the whole case-control cohort or age-at-onset risk effect among AD patients.
高温需求 1（HTRA1）基因是阿尔茨海默病（AD）的一个合理风险因素，因为它编码一种已知能降解淀粉样β肽的蛋白酶。在这里，我们研究了来自芬兰的大型基于临床的病例对照队列中，HTRA1 基因或其附近区域的单核苷酸多态性（SNP）是否与 AD 相关。我们没有观察到 HTRA1 SNP 与整个病例对照队列中的 AD 之间存在显著关联，也没有观察到 AD 患者发病年龄风险效应的关联。
