Lopes W A, Radominski R B, Rosário Filho N A, Leite N
Department of Physical Education, Faculdade Guairacá, Brazil.
Allergol Immunopathol (Madr). 2009 Jul-Aug;37(4):175-9. doi: 10.1016/j.aller.2009.03.001. Epub 2009 Sep 23.
Assess the frequency and severity of exercise-induced bronchospasm (EIB) in obese adolescents.
A cross-sectional descriptive study involving 80 adolescents of both genders, aged 10-16 years-old, divided into four groups according to clinical history of asthma and/or allergic rhinitis and body mass index as follows: asthmatic obese (n = 18); asthmatic non-obese (n = 21); obese non-asthmatic (n = 26); and healthy individuals (n = 15). An exercise bronchoprovocation test was used for EIB diagnosis, considered positive when the forced expiratory volume in one second (FEV(1)) decreased > or = 15% in relation to pre-exercise FEV(1). Maximum percent fall in FEV(1) (MF%FEV(1)) and area above the curve (AAC(0-30)) were calculated to evaluate EIB severity and recovery.
No significant difference was found in EIB frequency between asthmatic obese (50.0%) and asthmatic non-obese (38.0%) individuals or between obese non-asthmatics (11.5%) and healthy individuals (6.7%). However, the MF%FEV(1) and AAC(0-30) were significantly greater in the asthmatic obese group compared to the asthmatic non-obese (37.7% and 455 vs 24.5% and 214, p<0.03).
Obesity did not contribute to increased EIB frequency in asthmatics and non-asthmatics. However, obesity did contribute to increased EIB severity and recovery among asthmatics.
评估肥胖青少年运动诱发支气管痉挛（EIB）的频率和严重程度。
一项横断面描述性研究，涉及80名年龄在10 - 16岁的青少年，根据哮喘和/或过敏性鼻炎的临床病史以及体重指数分为四组：哮喘肥胖组（n = 18）；哮喘非肥胖组（n = 21）；肥胖非哮喘组（n = 26）；健康个体组（n = 15）。采用运动支气管激发试验诊断EIB，当一秒用力呼气容积（FEV(1)）相对于运动前FEV(1)下降≥15%时判定为阳性。计算FEV(1)的最大下降百分比（MF%FEV(1)）和曲线以上面积（AAC(0 - 30)）以评估EIB的严重程度和恢复情况。
哮喘肥胖个体（50.0%）和哮喘非肥胖个体（38.0%）之间，以及肥胖非哮喘个体（11.5%）和健康个体（6.7%）之间，EIB频率无显著差异。然而，与哮喘非肥胖组相比，哮喘肥胖组的MF%FEV(1)和AAC(0 - 30)显著更高（分别为37.7%和455，以及24.5%和214，p<0.03）。
肥胖对哮喘患者和非哮喘患者EIB频率的增加无影响。然而，肥胖确实导致哮喘患者的EIB严重程度增加和恢复时间延长。
