Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Parkinsonism Relat Disord. 2010 Feb;16(2):119-23. doi: 10.1016/j.parkreldis.2009.08.009. Epub 2009 Sep 23.
This study was conducted to evaluate the prevalence of malnutrition among patients with Parkinson's disease (PD) and determine the associations between malnutrition and non-motor symptoms (NMS).
We conducted a cross-sectional assessment of 117 consecutive outpatients with PD and their respective caregivers. The participants were interviewed and assessed using various scales, including the Mini Nutritional Assessment (MNA), Non-Motor Symptoms questionnaire for Parkinson's disease (NMS quest), Mini-mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Geriatric Depression Scale (GDS), and Hamilton Anxiety Scale (HAMA). We also investigated the socio-demographic characteristics of the subjects.
The prevalence of malnutrition (MNA score < 17) was 1.71%, and 19.66% patients were at risk of malnutrition (17 <or= MNA score <or= 23.5). Poor nutrition (malnutrition and at risk of malnutrition) was associated with some of the NMS including the constipation, vomiting, loss of interest, inability to concentrate and sadness, and high scores in PSQI, GDS, and HAMA. Constipation (OR, 6.646; 95% CI, 1.561-28,300; P = 0.010) and GDS scores (OR, 1.166; 95% CI, 1.042-1.304; P = 0.007) were considered to be the 2 most important predictors of nutritional impairment.
Nearly 22% of PD patients were malnourished or at the risk of malnutrition and the negative association between NMSs and nutritional care needs to be determined by further studies.
本研究旨在评估帕金森病（PD）患者的营养不良患病率，并确定营养不良与非运动症状（NMS）之间的关系。
我们对 117 例连续的 PD 门诊患者及其各自的照顾者进行了横断面评估。通过使用 Mini Nutritional Assessment（MNA）、帕金森病非运动症状问卷（NMS quest）、Mini-mental State Examination（MMSE）、Pittsburgh 睡眠质量指数（PSQI）、Epworth 嗜睡量表（ESS）、老年抑郁量表（GDS）和汉密尔顿焦虑量表（HAMA）等各种量表对参与者进行访谈和评估。我们还调查了受试者的社会人口统计学特征。
营养不良（MNA 评分<17）的患病率为 1.71%，19.66%的患者有营养不良风险（17≤MNA 评分≤23.5）。营养不良（营养不良和有营养不良风险）与一些 NMS 有关，包括便秘、呕吐、兴趣丧失、注意力不集中和悲伤，以及 PSQI、GDS 和 HAMA 评分较高。便秘（OR，6.646；95%CI，1.561-28,300；P=0.010）和 GDS 评分（OR，1.166；95%CI，1.042-1.304；P=0.007）被认为是营养损害的 2 个最重要的预测因素。
近 22%的 PD 患者存在营养不良或有营养不良风险，需要进一步研究确定 NMS 与营养护理之间的负相关关系。
