Biotechnology Research Center, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Plant Cell Physiol. 2009 Nov;50(11):1977-81. doi: 10.1093/pcp/pcp130. Epub 2009 Sep 24.
Antimony (Sb) is toxic to organisms including plants. Although it is not essential to organisms, plants take up Sb from the environment. In this study, we identified an antimonite [Sb(III)] transporter from Arabidopsis thaliana. We examined the Sb(III) tolerance of the disruption mutant plants of arsenite [As(III)] transporters, nodulin 26-like intrinsic proteins (NIPs), since Sb(III) is similar to As(III) in structure. One of the mutants, nip1;1, showed Sb(III) tolerance and accumulated less Sb. Furthermore, yeast expressing NIP1;1 accumulated twice as much Sb as control. These data indicate that NIP1;1 transports Sb(III) and determines the Sb(III) sensitivity of A. thaliana.
锑（Sb）对包括植物在内的生物体有毒。尽管锑不是生物体必需的，但植物会从环境中摄取 Sb。在这项研究中，我们从拟南芥中鉴定出一种亚锑酸盐[Sb（III）]转运蛋白。我们研究了砷酸盐[As（III）]转运蛋白、类根瘤蛋白 26 内在蛋白（NIPs）的缺失突变体植物对 Sb（III）的耐受性，因为 Sb（III）在结构上与 As（III）相似。其中一个突变体 nip1;1 表现出 Sb（III）耐受性，积累的 Sb 较少。此外，表达 NIP1;1 的酵母积累的 Sb 是对照的两倍。这些数据表明 NIP1;1 转运 Sb（III），并决定拟南芥对 Sb（III）的敏感性。
