Fundació Caubet-CIMERA Illes Balears, CIMERA, Bunyola, Spain.
Chest. 2010 Feb;137(2):333-40. doi: 10.1378/chest.09-1264. Epub 2009 Sep 25.
The prevalence of airflow limitation (AL) in patients with cardiovascular disease (CVD) is unknown, and whether AL is adequately diagnosed and treated in these patients has not been investigated before, to our knowledge.
We compared clinical and spirometric data in three groups of individuals. Two of them were participants in the follow-up of an ongoing population-based study according to the presence or absence of CVD. The third group included patients with coronary artery disease (CAD) confirmed by coronariography regularly visited at a tertiary referral university hospital. AL was defined according to the Global Initiative for Obstructive Lung Disease guidelines.
We studied 450 population participants without CVD, 52 population participants with CVD, and 119 hospital patients with CAD. The prevalence of AL in these three groups was 17.5% (95% CI, 14.0-21.0), 19.2% (95% CI, 8.1-30.7), and 33.6% (95% CI, 25.0-42.2), respectively (P < .05). Underdiagnosis of AL ranged from 60% in population participants with CVD up to 87.2% in hospital patients with CAD. Sixty percent of those with spirometrically confirmed AL (in all three groups) did not receive any respiratory treatment.
AL is frequent in individuals with CVD, particularly in those with CAD attended in the hospital, is largely underdiagnosed and therefore is highly undertreated.
Clinicaltrials.gov; Identifier: NCT00787748.
心血管疾病（CVD）患者气流受限（AL）的患病率尚不清楚，据我们所知，以前并未研究过这些患者中 AL 是否得到充分诊断和治疗。
我们比较了三组个体的临床和肺功能数据。其中两组是根据是否存在 CVD 进行的正在进行的基于人群的研究随访的参与者。第三组包括定期在三级转诊大学医院就诊的经冠状动脉造影证实为冠心病（CAD）的患者。AL 根据全球阻塞性肺病倡议指南定义。
我们研究了 450 名无 CVD 的人群参与者、52 名有 CVD 的人群参与者和 119 名有 CAD 的医院患者。这三组人群的 AL 患病率分别为 17.5%（95%CI，14.0-21.0）、19.2%（95%CI，8.1-30.7）和 33.6%（95%CI，25.0-42.2）（P<.05）。AL 的漏诊率从 CVD 人群参与者的 60%到医院 CAD 患者的 87.2%不等。所有三组中，60%经肺功能检查确诊为 AL 的患者未接受任何呼吸治疗。
CVD 患者的 AL 很常见，尤其是在医院就诊的 CAD 患者中，AL 大量漏诊，因此治疗不足。
Clinicaltrials.gov；标识符：NCT00787748。
