Borison R L, Albrecht J W, Diamond B I
Department of Psychiatry, Medical College of Georgia, Augusta.
Psychopharmacol Bull. 1990;26(2):207-10.
Ipsapirone is an azopirone derivative that selectively interacts with serotonin-1A (5-HT1A) receptors and fails to affect other neurotransmitter receptors. In this study, ipsapirone at 15 mg or 30 mg was compared with diazepam at 15 mg and placebo in a double-blind, random assignment study design in patients with generalized anxiety disorder (GAD). During 4 weeks of treatment, both active drugs were therapeutically superior to placebo, without significant drug vs. drug therapeutic differences. The side-effect profile of ipsapirone at 15 mg was favorable compared to diazepam, but at 30 mg ipsapirone produced significant gastrointestinal disturbances.
伊沙匹隆是一种氮杂螺环酮衍生物，它能选择性地与5-羟色胺-1A（5-HT1A）受体相互作用，而不会影响其他神经递质受体。在本研究中，采用双盲、随机分组研究设计，将15毫克或30毫克的伊沙匹隆与15毫克的地西泮及安慰剂进行比较，研究对象为广泛性焦虑症（GAD）患者。在4周的治疗期间，两种活性药物在治疗效果上均优于安慰剂，且药物之间没有显著的治疗差异。与地西泮相比，15毫克伊沙匹隆的副作用较小，但30毫克伊沙匹隆会引起明显的胃肠道不适。
