Wheatley D
J Clin Psychiatry. 1982 Dec;43(12 Pt 2):92-4.
The efficacy and safety of buspirone (Buspar), diazepam (Valium), and placebo were compared in a 3-week double-blind study of 131 patients with scores of at least 15 on the Hamilton Rating Scale for Anxiety. Active drugs were administered orally in 5-mg tablets to a maximum dose of 10 mg t.i.d. Buspirone was given to 43 patients, diazepam to 46 and placebo to 42. There was significant improvement in all three treatment groups at 1 and 2 weeks, with further significant improvement with both active drugs, but not with placebo, at 3 weeks. The incidence of side effects reported voluntarily by patients was similar with the two active drugs, but drowsiness was significantly more frequent with diazepam.
在一项针对131名汉密尔顿焦虑量表评分至少为15分的患者进行的为期3周的双盲研究中，比较了丁螺环酮（布斯帕）、地西泮（安定）和安慰剂的疗效与安全性。活性药物以5毫克片剂口服给药，最大剂量为每日三次，每次10毫克。43名患者服用丁螺环酮，46名患者服用地西泮，42名患者服用安慰剂。在第1周和第2周时，所有三个治疗组均有显著改善，在第3周时，两种活性药物进一步显著改善，但安慰剂组未出现进一步显著改善。患者自愿报告的副作用发生率在两种活性药物中相似，但地西泮导致的嗜睡明显更频繁。
