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用于肠胃外疫苗和药物递送的角鲨烯乳剂。

Squalene emulsions for parenteral vaccine and drug delivery.

作者信息

Fox Christopher B

机构信息

Infectious Disease Research Institute, Seattle, WA 98104, USA.

出版信息

Molecules. 2009 Sep 1;14(9):3286-312. doi: 10.3390/molecules14093286.

DOI:10.3390/molecules14093286
PMID:19783926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6254918/
Abstract

Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.

摘要

角鲨烯是一种直链三萜，被广泛用作药物和疫苗递送的肠胃外乳剂的主要成分。在本综述中，介绍了角鲨烯的化学结构和来源。此外，还在肠胃外制剂的背景下对角鲨烯乳剂的物理化学和生物学特性进行了评估。讨论了含有角鲨烯或角鲨烷的历史和当前肠胃外乳剂产品。还探讨了基于角鲨烯的产品的安全性。最后，研究了角鲨烯乳剂表征的分析技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/bb2efb63e166/molecules-14-03286-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/f2fa64e0d8a5/molecules-14-03286-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/62ddc5d5ce0f/molecules-14-03286-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/bbad53cb6c55/molecules-14-03286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/6fc77ca8f2af/molecules-14-03286-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/3b3b29294840/molecules-14-03286-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/bb2efb63e166/molecules-14-03286-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/f2fa64e0d8a5/molecules-14-03286-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/62ddc5d5ce0f/molecules-14-03286-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/bbad53cb6c55/molecules-14-03286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/6fc77ca8f2af/molecules-14-03286-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/3b3b29294840/molecules-14-03286-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0580/6254918/bb2efb63e166/molecules-14-03286-g006.jpg

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