Asano Tatsuhiko, Kobayashi Yoshio, Fukushima Kenichi, Iwata Yo, Kitahara Hideki, Ishio Naoki, Nakayama Takashi, Kuroda Nakabumi, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
Heart Vessels. 2009 Sep;24(5):335-9. doi: 10.1007/s00380-008-1130-1. Epub 2009 Sep 27.
There is little information about the relationship between balloon inflation time and sirolimus-eluting stent (SES) expansion. In this randomized intravascular ultrasound (IVUS) study, 92 de novo lesions in native coronary arteries that underwent SES implantation were enrolled. Sirolimus-eluting stent was implanted using an inflation pressure of 14 atm. Stent balloon was gradually inflated until 14 atm in 10 s. In the short inflation group, it was deflated immediately after an image of the balloon inflated at 14 atm was taken. Stent balloon inflation lasted 60 s in the long inflation group. Intravascular ultrasound was then performed. The long balloon inflation resulted in a larger stent cross-sectional area (4.9 +/- 1.6 mm(2) vs 4.3 +/- 1.4 mm(2), P < 0.05) and expansion (71% +/- 13% vs 60% +/- 13%, P < 0.001) compared to the short balloon inflation, although stent expansion was relatively low in both groups. The relatively longer balloon inflation time using an inflation pressure of 14 atm results in better SES expansion. However, in the majority of lesions, adequate stent expansion is not achieved even using long balloon inflation, if it is inflated at 14 atm.
关于球囊充盈时间与西罗莫司洗脱支架（SES）扩张之间的关系，目前所知甚少。在这项随机血管内超声（IVUS）研究中，纳入了92例接受SES植入的天然冠状动脉原发病变。使用14个大气压的充盈压力植入西罗莫司洗脱支架。支架球囊在10秒内逐渐充盈至14个大气压。在短充盈组中，在获取球囊在14个大气压下充盈的图像后立即将其放气。在长充盈组中，支架球囊充盈持续60秒。然后进行血管内超声检查。与短球囊充盈相比，长球囊充盈导致更大的支架横截面积（4.9±1.6平方毫米对4.3±1.4平方毫米，P<0.05）和扩张程度（71%±13%对60%±13%，P<0.001），尽管两组的支架扩张程度都相对较低。使用14个大气压的充盈压力时，相对较长的球囊充盈时间会导致更好的SES扩张。然而，在大多数病变中，即使使用长球囊充盈，如果在14个大气压下充盈，也无法实现充分的支架扩张。
