Alexandrova R
Institute of Experimental Pathology and Parasitology, Department of Oncovirology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
J BUON. 2009 Sep;14 Suppl 1:S23-32.
Gene therapy is a new and innovative approach to the treatment of malignant neoplasms, although it is still not capable of eradicating cancer in humans. Selection of the appropriate vector with maximal efficiency and minimal toxicity is crucial for gene therapy and numerous viral and non-viral (synthetic) methods for gene transfer have been developed. There are different gene therapy approaches for cancer treatment such as: 1) gene correction; 2) molecular chemotherapy; 3) proapoptotic gene therapy; 4) antiangiogenic gene therapy; 5) immune gene therapy; and 6) modulation of drug resistance/sensitivity. Cancer gene therapy represents one of the most rapidly developing areas in preclinical and clinical research. However, some problems need to be solved to make sure this strategy is safe, effective and long-lasting before it becomes routinely adopted in clinical practice.
基因治疗是一种治疗恶性肿瘤的全新且创新的方法，尽管它目前仍无法根除人类癌症。选择效率最高且毒性最小的合适载体对于基因治疗至关重要，并且已经开发出了多种用于基因转移的病毒和非病毒（合成）方法。癌症治疗有不同的基因治疗方法，例如：1）基因校正；2）分子化疗；3）促凋亡基因治疗；4）抗血管生成基因治疗；5）免疫基因治疗；以及6）耐药性/敏感性调节。癌症基因治疗是临床前和临床研究中发展最为迅速的领域之一。然而，在该策略被临床实践常规采用之前，需要解决一些问题以确保其安全、有效且持久。
