人类内源性逆转录病毒在黑色素瘤中的作用。

The role of human endogenous retroviruses in melanoma.

机构信息

Department of Dermatology, Chelsea and Westminster Hospital, Imperial College Faculty of Medicine, London, U.K.

出版信息

Br J Dermatol. 2009 Dec;161(6):1225-31. doi: 10.1111/j.1365-2133.2009.09415.x. Epub 2009 Jul 20.

DOI:10.1111/j.1365-2133.2009.09415.x

PMID:19785608

Abstract

Sequencing of the human genome has established that our DNA harbours many endogenous retrovirus (ERV) sequences, remnants of ancestral exogenous retroviral infections fixed in the germline DNA. In recent years, human ERVs (HERVs) have been implicated in melanomagenesis. Retrovirus-like particles and the expression of HERV mRNA and proteins have been demonstrated in melanoma tissue. In addition, antibodies to HERV proteins have been observed in patients with melanoma. In vitro and mouse models have provided fascinating insights into the potential mechanisms of HERVs in melanomagenesis. This review considers the evidence associating HERVs with melanoma.

摘要

人类基因组测序已经确定，我们的 DNA 中含有许多内源性逆转录病毒 (ERV) 序列，这些序列是祖先外源逆转录病毒感染在生殖系 DNA 中固定下来的遗迹。近年来，人类内源性逆转录病毒 (HERV) 已被认为与黑色素瘤的发生有关。在黑色素瘤组织中已经证明存在逆转录病毒样颗粒以及 HERV mRNA 和蛋白质的表达。此外，在患有黑色素瘤的患者中也观察到了针对 HERV 蛋白的抗体。体外和小鼠模型为 HERV 在黑色素瘤发生中的潜在机制提供了引人入胜的见解。这篇综述考虑了将 HERV 与黑色素瘤联系起来的证据。