Milte Catherine M, Sinn Natalie, Howe Peter R C
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.
Nutr Rev. 2009 Oct;67(10):573-90. doi: 10.1111/j.1753-4887.2009.00229.x.
Interest in the role of polyunsaturated fatty acids (PUFAs), particularly long-chain (LC) omega-3 (n-3) PUFAs, in mental health is increasing. This review investigates whether n-3 PUFA levels are abnormal in people with three prevalent mental health problems - attention deficit hyperactivity disorder, depression, and dementia. Data sources included PubMed, Web of Science, and bibliographies of papers published in English that describe PUFA levels in the circulation of individuals who have these mental health conditions. Although abnormal blood PUFA levels were reported in a number of studies, weighted comparisons of PUFA status showed no significant differences overall between people with mental health problems and controls. Whether those with low n-3 PUFA status are likely to be more responsive to n-3 PUFA supplementation is not yet resolved. Further studies assessing PUFA levels and mental status with greater uniformity are required in order to clarify the relationship between LC n-3 PUFA status and mental health.
对多不饱和脂肪酸（PUFAs），尤其是长链（LC）ω-3（n-3）多不饱和脂肪酸在心理健康方面作用的关注正在增加。本综述调查了患有三种常见心理健康问题——注意力缺陷多动障碍、抑郁症和痴呆症的人群中n-3多不饱和脂肪酸水平是否异常。数据来源包括PubMed、科学网以及以英文发表的描述这些心理健康状况个体循环中多不饱和脂肪酸水平的论文参考文献。尽管多项研究报告了血液中多不饱和脂肪酸水平异常，但多不饱和脂肪酸状态的加权比较显示，有心理健康问题的人群与对照组总体上无显著差异。n-3多不饱和脂肪酸水平低的人群是否可能对补充n-3多不饱和脂肪酸更敏感，这一问题尚未解决。需要进一步开展评估多不饱和脂肪酸水平和心理状态且一致性更高的研究，以阐明LC n-3多不饱和脂肪酸状态与心理健康之间的关系。
