Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
J Dermatol. 2009 Oct;36(10):525-8. doi: 10.1111/j.1346-8138.2009.00694.x.
Photodynamic therapy with topical 5-aminolevulinic acid is an effective and safe treatment for actinic keratosis and superficial non-melanoma skin cancer. Further, some studies have reported good efficacy when using photodynamic therapy to treat viral warts. The light-emitting diode is an incoherent, narrow-spectrum light source. The purpose of this study is to evaluate the efficacy of photodynamic therapy using a light-emitting diode for viral warts. Six patients with a total of 41 foot and hand warts were recruited in this study. They were treated with 20% 5-aminolevulinic acid cream under occlusion for 5 h. Thereafter, the treated area was irradiated with the light from a red light-emitting diode (633 +/- 6 nm) with a dose of 126 J/cm(2). This treatment was repeated at 2- or 3-week intervals. The rate of improvement observed in patients was 68.3%. The adverse effects included mild to moderate pain and erythema, which was well-tolerated by all six patients. No patients withdrew from the study due to the adverse effects. Photodynamic therapy with topical 5-aminolevulinic acid using the light from a red light-emitting diode has the advantage of non-invasiveness, minimal associated adverse reactions, and production of good results in a significant proportion of cases: therefore, it is an alternative treatment for recalcitrant viral warts.
局部外用 5-氨基酮戊酸光动力疗法是一种有效且安全的治疗光化性角化病和浅表非黑素瘤皮肤癌的方法。此外，一些研究报告称，光动力疗法治疗病毒性疣也具有良好的疗效。发光二极管是一种非相干的、窄谱光源。本研究旨在评估发光二极管光动力疗法治疗病毒性疣的疗效。本研究共招募了 6 名患者，总计 41 例手部和足部疣。他们使用 20%的 5-氨基酮戊酸乳膏进行局部封包治疗，持续 5 小时。然后，用波长为 633nm（+/-6nm）的红光发光二极管（剂量为 126J/cm²）照射治疗区域。每 2-3 周重复一次治疗。患者的改善率为 68.3%。不良反应包括轻度至中度疼痛和红斑，所有 6 名患者均能耐受。没有患者因不良反应而退出研究。局部外用 5-氨基酮戊酸光动力疗法联合红光发光二极管治疗具有非侵入性、不良反应轻微、多数病例疗效显著等优点：因此，是治疗顽固性病毒性疣的一种替代疗法。
