光动力疗法在医学实践中的应用。

Aebisher David, Rogóż Kacper, Myśliwiec Angelika, Dynarowicz Klaudia, Wiench Rafał, Cieślar Grzegorz, Kawczyk-Krupka Aleksandra, Bartusik-Aebisher Dorota

Department of Photomedicine and Physical Chemistry, Medical College of The Rzeszów University, Rzeszów, Poland.

English Division Science Club, Medical College of The Rzeszów University, Rzeszów, Poland.

Front Oncol. 2024 May 8;14:1373263. doi: 10.3389/fonc.2024.1373263. eCollection 2024.

Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT's efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT's dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT's principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

癌症治疗，尤其是针对敏感区域附近的肿瘤，需要精确的治疗。本综述探讨了光动力疗法（PDT），这是一种利用光敏剂（PS）、特定波长的光和氧气来有效靶向癌症的方法。最近的进展证实了PDT的疗效，它利用活性氧的产生来诱导癌细胞死亡。PDT有着数十年的历史，其不断发展已将其应用扩展到皮肤科、肿瘤学和牙科领域。本综述旨在剖析PDT从起源到当代医学应用的原理，突出其在现代癌症治疗策略中的作用。