Butler C K, Smith F M, Cardinal R, Murphy D A, Hopkins D A, Armour J A
Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Am J Physiol. 1990 Nov;259(5 Pt 2):H1365-73. doi: 10.1152/ajpheart.1990.259.5.H1365.
The purpose of the present study was to examine cardiac effects induced by electrical stimulation (1-4 V, 1 ms, 200 Hz) of discrete loci within the ganglionated plexi located on canine atria and ventricles. When 20 loci in the right atrial ventral ganglionated plexi of 11 anesthetized open-chest dogs were stimulated, bradycardia and/or right and left atrial force suppression occurred when, on average, 15% of these loci were stimulated. Bradycardia and atrial force suppression were elicited when, on average, 8% of 15 loci in the left atrial ventral ganglionated plexi of eight dogs was stimulated. When these loci were restimulated after acute decentralization, cardiac responses were attenuated or occasionally eliminated. After atropine (1 mg/kg iv) administration, repeat stimulation of loci in the right but not left atrial ganglionated plexus induced tachycardia. Stimulation of loci in the right ventricular ganglionated plexus after the subsequent administration of desipramine (1 mg/kg iv) in six dogs resulted in an increase in right ventricular conus intramyocardial pressure. After hexamethonium administration (10 mg/kg iv, followed by a continuous infusion of 1 mg.kg-1.min-1), sympathetic responses were no longer elicited from one of the five dogs in which loci in the right atrial ganglionated plexi and from two of the six dogs in which loci of the right ventricular ganglionated plexus had elicited responses. We conclude that atrial and ventricular ganglionated plexi contain efferent parasympathetic, efferent sympathetic, and afferent neurons.
本研究的目的是检测对犬心房和心室神经节丛内离散位点进行电刺激（1 - 4 V，1 ms，200 Hz）所诱发的心脏效应。在11只麻醉开胸犬的右心房腹侧神经节丛中刺激20个位点时，平均刺激其中15%的位点会出现心动过缓和/或左右心房力抑制。在8只犬的左心房腹侧神经节丛中刺激15个位点，平均刺激其中8%的位点时可诱发心动过缓和心房力抑制。在急性去神经支配后再次刺激这些位点，心脏反应减弱或偶尔消失。静脉注射阿托品（1 mg/kg）后，再次刺激右心房而非左心房神经节丛中的位点会诱发心动过速。在6只犬静脉注射地昔帕明（1 mg/kg）后，刺激右心室神经节丛中的位点会导致右心室圆锥部心肌内压升高。静脉注射六甲铵（10 mg/kg，随后以1 mg·kg-1·min-1持续输注）后，在右心房神经节丛位点曾诱发反应的5只犬中的1只以及右心室神经节丛位点曾诱发反应的6只犬中的2只，不再引发交感反应。我们得出结论，心房和心室神经节丛包含传出副交感神经、传出交感神经和传入神经元。
