Ardell J L, Butler C K, Smith F M, Hopkins D A, Armour J A
Department of Physiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Am J Physiol. 1991 Mar;260(3 Pt 2):H713-21. doi: 10.1152/ajpheart.1991.260.3.H713.
The spontaneous activity of 175 neurons located in the ventral right atrial and ventral interventricular ganglionated plexi was recorded in eight anesthetized dogs, the hearts of which were chronically decentralized at least 2 wk before recordings were made. Ganglia were subsequently identified anatomically in the immediate vicinity of the recording sites. Spontaneous activity was correlated with the cardiac cycle in 57% of the atrial and 62% of the ventricular neurons and with the respiratory cycle in 29% of the atrial and 28% of the ventricular neurons. Spontaneous cardiovascular-related activity was recorded when systemic arterial pressure was between 80 and 175 mmHg. The activity of 23 atrial and 15 ventricular neurons was altered when discrete regions of the heart were mechanically distorted by gentle touch. These data imply that cardiac ganglionated plexi contain afferent neurons that receive inputs from limited regions of the heart. The spontaneous activity generated by intracardiac neurons was not altered when extracardiac tissues were distorted. These results demonstrate that neurons in ganglia on chronically decentralized hearts can generate spontaneous activity, a large fraction of which is correlated with cardiovascular or respiratory events.
在八只麻醉犬中记录了位于右心房腹侧和室间神经节丛的175个神经元的自发活动，这些犬的心脏在记录前至少已慢性去神经支配2周。随后在记录部位附近通过解剖学方法识别神经节。57%的心房神经元和62%的心室神经元的自发活动与心动周期相关，29%的心房神经元和28%的心室神经元的自发活动与呼吸周期相关。当体动脉压在80至175 mmHg之间时记录到了与心血管相关的自发活动。当心脏的离散区域受到轻柔触摸而发生机械变形时，23个心房神经元和15个心室神经元的活动发生了改变。这些数据表明心脏神经节丛包含从心脏有限区域接收输入的传入神经元。当心脏外组织发生变形时，心内神经元产生的自发活动并未改变。这些结果表明，慢性去神经支配心脏上神经节中的神经元可以产生自发活动，其中很大一部分与心血管或呼吸事件相关。
