Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria.
Vaccine. 2009 Nov 23;27(50):7027-30. doi: 10.1016/j.vaccine.2009.09.068. Epub 2009 Sep 26.
Five and 6 years post-booster, immunity to tick-borne encephalitis (TBE) virus was assessed in 225 and 195 vaccinees, respectively, out of 430 healthy volunteers with at least three TBE-immunizations prior to study inclusion and booster intervals exceeding recommended limits. Neutralizing antibody titers of > or = 1:10 (reliable level of protection) were present in 86-96% depending on age group, with lower percentages in participants >60 years. TBE antibody levels remained stable for many years in most vaccinees. However, in a few persons a shorter period of protection against TBE was indicated. Therefore, recommendations on booster intervals in TBE endemic areas should be adapted by weighting the risk of infection against the risk of short-lived immunity.
在研究纳入时，有 430 名健康志愿者至少进行了三次 TBE 免疫，并且加强针间隔超过了推荐的限制，在分别为 5 年和 6 年后加强针后，评估了 225 名和 195 名疫苗接种者对蜱传脑炎（TBE）病毒的免疫力。根据年龄组的不同，中和抗体滴度 >或= 1:10（可靠的保护水平）存在于 86-96%的人群中，在> 60 岁的参与者中百分比较低。在大多数疫苗接种者中，TBE 抗体水平多年来保持稳定。然而，在少数人中，TBE 的保护期较短。因此，应根据感染风险与短暂免疫风险之间的权衡，调整 TBE 流行地区加强针间隔的建议。
